Beta Cohort — August 2026

Adverse event reporting,
finally automated.

AE Connect handles intake, MedDRA coding, causality assessment, and FDA filing — so your drug safety team can focus on science, not paperwork.

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21 CFR Part 11 compliant
AI-powered triage
E2B XML export
65%
less time per case
15-day
deadline never missed
AE Connect — Case Dashboard
AE-2026-00341 Expedited · 15-Day
Investigational Drug A · 9.4 mg/kg IV
Serious unexpected: Grade 3 thrombocytopenia
Reporter: HCP Received: Today Due: 13 days
AI Auto-Triage Complete
MedDRA PTThrombocytopenia (10043554)
SOCBlood & lymphatic disorders
CausalityProbable (WHO-UMC)
Regulatory action→ File MedWatch 15-day
AE-2026-00338 Filed ✓
Investigational Drug B · 3 mg inh.
Non-serious expected: Mild headache, resolved
Built for teams like
Day One Biopharmaceuticals Verona Pharma ImmunityBio Madrigal Pharmaceuticals BridgeBio Pharma Rhythm Pharmaceuticals Arcus Biosciences

PV compliance is broken
for small biotech

Your first approved product means you're legally obligated to report adverse events — forever. Most lean teams are drowning in manual processes that cost a fortune and create compliance risk.

⏱️

Hours wasted per case

Manual intake, MedDRA lookup, narrative writing, and E2B formatting takes 3–5 hours per case. With 500+ cases a year, that's entire headcount consumed by data entry.

$131K+ in annual labor per 500 cases
🚨

15-day deadlines don't wait

Expedited reports must reach the FDA within 15 calendar days of awareness. Manual tracking fails at scale — and late filings mean Warning Letters.

FDA enforcement on the rise
💸

Legacy systems are unaffordable

Argus, Veeva Vault Safety, and similar platforms cost $80K–$250K+ annually — built for Big Pharma, priced out of reach for emerging biotech.

AE Connect costs up to 75% less

From report to filed
in minutes, not days

AE Connect handles the full adverse event lifecycle — from the moment a reporter submits to the moment the E2B file lands at the FDA.

01

Reporter Intake

HCPs, patients, and literature sources submit via a branded, configurable intake form. No phone tag. No fax.

Smart form validation
02

AI Auto-Triage

Claude AI instantly suggests MedDRA coding, seriousness criteria, expectedness, and causality assessment.

MedDRA v27 dictionary
03

Medical Review

Your team reviews AI suggestions, edits the narrative, and approves the case — in a fraction of the normal time.

Full audit trail
04

Regulatory Filing

One-click E2B XML export and direct MedWatch submission. 15-day deadlines tracked automatically.

FDA & EMA ready

Everything your drug safety
team actually needs

No bloat. No features built for 500-person PV departments. AE Connect is built for lean teams that need to move fast and stay compliant.

🤖

AI-Powered Auto-Triage

Claude AI reads every incoming case and suggests MedDRA PT/SOC/LLT codes, causality assessment using WHO-UMC criteria, seriousness, and regulatory reporting recommendation — before your team touches it.

📋

Configurable Intake Portal

A branded, validated reporter intake form that captures all ICH E2B(R3) required fields — adaptable for HCP, patient, and literature reports.

Regulatory Timeline Tracking

Every case gets an automatic clock. 15-day expedited, 7-day fatal/life-threatening, and periodic report deadlines tracked and escalated automatically.

📤

E2B XML & MedWatch Export

One-click generation of ICH E2B(R3) XML files for FDA and EMA submission. Direct MedWatch integration. No manual data re-entry.

🔒

21 CFR Part 11 Compliance

Complete electronic audit trail with timestamps, user attribution, and change history on every case action. Supports your CSV process with IQ/OQ documentation on Scale+.

👥

Unlimited Users, Role-Based Access

No per-seat pricing. Drug Safety Associates, Medical Directors, QA reviewers — all with appropriate access controls. Five-tier RBAC with admin dashboard.

65%
Reduction in time spent per AE case with AI auto-triage
$36K
Starting price — vs $80K–$250K for legacy platforms
320+
US biotech companies that need exactly this solution today

Built for the
regulated world

AE Connect is designed from the ground up for 21 CFR Part 11 and ICH E2B compliance. Not bolted on after the fact.

21 CFR Part 11 Audit Trail
ICH E2B(R3) Compliant
HIPAA Compliant Infrastructure
MedDRA v27 Dictionary
FDA MedWatch Direct Submission
EMA EudraVigilance Ready
SOC 2 Type II (in progress)
IQ/OQ Validation Docs (Scale+)
Business Associate Agreement
Role-Based Access Control
Beta Cohort Open · 7 Slots Remaining

Ready to modernize your
adverse event program?

Book a 20-minute discovery call. No deck, no pressure — just an honest conversation about your PV program and whether AE Connect is the right fit.

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Beta pricing: 40% off first year · Starts August 2026 · First 10 companies only